Project P10
Regulation and adaptation of G-protein coupled receptors/adenylyl cyclase/cAMP signaling networks in brown/beige AT
© Dagmar Wachten
G-protein coupled receptor (GPCR) signaling pathways, coupling to adenyly cyclases (ACs) and cAMP signaling, constitute the central signaling pathway for activating lipolysis and energy expenditure in thermogenic adipocytes. In this project, we will study the function of GPCRs and ACs specifically expressed in brown and beige adipose tissue and their regulation depending on the activation status of thermogenic AT in vitro and in vivo. Thereby, we will unravel how GPCR/AC signaling adapts to physiological and pathological stimuli in the context of adaptive thermogenesis and systemic energy metabolism.
Project Leaders
Prof. Dr. med. Alexander Pfeifer
Universitätsklinikum Bonn
Institut für Pharmakologie & Toxikologie
Venusberg-Campus 1 53127 Bonn
© Johann Saba
Prof. Dr. rer. nat. Dagmar Wachten
BMZ II
Venusberg-Campus 1
53127 Bonn
Institute of Innate Immunity
Department of Biophysical Imaging
© Barbara Frommann