Project P14
Molecular role of the mitochondrial unfolded protein response in white and brown adipose tissue for whole body glucose homeostasis
© Dr. Eva Rath
Functional disturbances of adipocyte mitochondria can affect systemic glucose tolerance via adipocyte-intrinsic mechanisms like impaired glucose uptake and altered differentiation processes (e.g. browning of WAT) as well as via metabolic- or endocrine-derived signals to remote tissues. Using new conditional knockout mouse models and high-fat diet feeding in combination with interventional studies employing pharmacological relevant substances, this project aims to unravel the role of MT-UPR signaling for the maintenance of adipocyte functions in WAT and BAT and its contribution to sustain whole body glucose homeostasis.
Project Leaders
Prof. Dr. rer. nat. Martin Klingenspor
Raum 1.89
Gregor-Mendel-Straße 2
85354 Freising
Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich
EKFZ – Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich
ZIEL – Institute for Food & Health, Technical University of Munich
© Magdalena Jooss
Dr. rer. nat. Eva Rath
Lehrstuhl für Ernährung und Immunologie
Gregor-Mendel-Straße 2
85354 Freising