Publications of the TRR 333

Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, Gohlke S, Frommolt P, Gnad T, Rada-Iglesias A, Pradas-Juni M, Schulz TJ, Wunderlich FT, Pfeifer A, Bartelt A, Jastroch M, Wachten D, Kornfeld JW. Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. Nat Metab. 2024 Apr 29. doi: 10.1038/s42255-024-01033-8. Epub ahead of print. PMID: 38684889.

Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein MY, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A. EPAC1 enhances brown fat growth and beige adipogenesis. Nat Cell Biol. 2024 Jan;26(1):113-123. doi: 10.1038/s41556-023-01311-9. Epub 2024 Jan 9. PMID: 38195707; PMCID: PMC10791580.

Worthmann A, Ridder J, Piel SYL, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer AW, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, Pertzborn P, Pauly M, Scholz JJ, Kundu S, Fuh MM, Neu A, Tödter K, Hempel M, Knippschild U, Semenkovich CF, Schlüter H, Heeren J, Scheja L, Kubisch C, Schlein C. Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use. Nat Commun. 2024 Jan 2;15(1):45. doi: 10.1038/s41467-023-44364-y. PMID: 38167725; PMCID: PMC10762034.

Wackerhage H, Hinrichs A, Wolf E, Hrabě de Angelis M. Turning fat into muscle: can this be an alternative to anti-obesity drugs such as semaglutide? J Physiol. 2024 Mar 1. doi: 10.1113/JP286430. Epub ahead of print. PMID: 38426245.

Graelmann F, Gondorf F, Majlesain Y, Niemann B, Klepac K, Gottschalk M, Mayer M, Iriady I, Hatzfeld P, Lindenberg S, Wunderling K, Thiele C, Abdullah Z, He W, Hiller K, Haendler K, Beyer M, Ulas T, Pfeifer A, Esser C, Weighardt H, Förster I, Reverte-Salisa L. Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis. bioRxiv 2024.02.22.581524; doi: https://doi.org/10.1101/2024.02.22.581524

Pfeifer A, Mikhael M, Niemann B. Inosine: novel activator of brown adipose tissue and energy homeostasis. Trends Cell Biol. 2024 Jan;34(1):72-82. doi: 10.1016/j.tcb.2023.04.007. Epub 2023 May 13. PMID: 37188562.

Quagliarini F, Makris K, Friano ME, Uhlenhaut NH. EJE Prize 2023: genes on steroids-genomic control of hepatic metabolism by the glucocorticoid receptor. Eur J Endocrinol. 2023 May 10;188(5):R111-R130. doi: 10.1093/ejendo/lvad048. PMID: 37119521.

Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein MY, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A, Pasparakis M. Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. 2023 Dec 20. doi: 10.1038/s41586-023-06857-0. Epub ahead of print. PMID: 38123683.

De Jong KA, Ehret S, Heeren J, Nikolaev VO. Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes. Cell Rep. 2023 May 30;42(5):112433. doi: 10.1016/j.celrep.2023.112433. Epub 2023 Apr 25. PMID: 37099421.

Correia CM, Præstholm SM, Havelund JF, Pedersen FB, Siersbæk MS, Ebbesen MF, Gerhart-Hines Z, Heeren J, Brewer J, Larsen S, Blagoev B, Færgeman NJ, Grøntved L. Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice. Endocrinology. 2023 Aug 28;164(10):bqad128. doi: 10.1210/endocr/bqad128. PMID: 37610219.

Siracusa F, Schaltenberg N, Kumar Y, Lesker TR, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks BP, Bönisch F, Fischer AW, Scognamiglio P, Pauly MJ, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker HW, Kretz O, Guse AH, Izbicki JR, Lassen KG, Strowig T, Schweizer M, Villablanca EJ, Elinav E, Huber S, Heeren J, Gagliani N. Short-term dietary changes can result in mucosal and systemic immune depression. Nat Immunol. 2023 Sep;24(9):1473-1486. doi: 10.1038/s41590-023-01587-x. Epub 2023 Aug 14. PMID: 37580603; PMCID: PMC10457203.

Schälte, Y., Fröhlich, F., Jost, P. J., Vanhoefer, J., Pathirana, D., Stapor, P., Lakrisenko, P., Wang, D., Raimúndez, E., Merkt, S., Schmiester, L., Städter, P., Grein, S., Dudkin, E., Doresic, D., Weindl, D., & Hasenauer, J. (2023). pyPESTO: A modular and scalable tool for parameter estimation for dynamic models, Bioinformatics, 2023, btad711, doi:10.1093/bioinformatics/btad711

Villaverde AF, Raimundez E, Hasenauer J, Banga JR. Assessment of Prediction Uncertainty Quantification Methods in Systems Biology. IEEE/ACM Trans Comput Biol Bioinform. 2023 May-Jun;20(3):1725-1736. doi: 10.1109/TCBB.2022.3213914. Epub 2023 Jun 5. PMID: 36223355.

Raimúndez E, Fedders M, Hasenauer J. Posterior marginalization accelerates Bayesian inference for dynamical models of biological processes. iScience. 2023 Sep 28;26(11):108083. doi: 10.1016/j.isci.2023.108083. PMID: 37867942; PMCID: PMC10589897.

Swietlik JJ, Bärthel S, Falcomatà C, Fink D, Sinha A, Cheng J, Ebner S, Landgraf P, Dieterich DC, Daub H, Saur D, Meissner F. Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation. Nat Commun. 2023 May 8;14(1):2642. doi: 10.1038/s41467-023-38171-8. PMID: 37156840; PMCID: PMC10167354.

Schlein C, Worthmann A, Piel S et al. Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use, 21 November 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1008467/v1]

Sun L, Laurila S, Lahesmaa M, Rebelos E, Virtanen KA, Schnabl K, Klingenspor M, Nummenmaa L, Nuutila P. Secretin modulates appetite via brown adipose tissue-brain axis. Eur J Nucl Med Mol Imaging. 2023 May;50(6):1597-1606. doi: 10.1007/s00259-023-06124-4. Epub 2023 Feb 11. PMID: 36764966; PMCID: PMC10119257.

Chamorro R, Jouffe C, Oster H, Uhlenhaut NH, Meyhöfer SM. When should I eat: A circadian view on food intake and metabolic regulation. Acta Physiol (Oxf). 2023 Mar;237(3):e13936. doi: 10.1111/apha.13936. Epub 2023 Jan 27. PMID: 36645134.

Fadel L, Dacic M, Fonda V, Sokolsky BA, Quagliarini F, Rogatsky I, Uhlenhaut NH. Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators. Pharmacol Ther. 2023 Nov;251:108531. doi: 10.1016/j.pharmthera.2023.108531. Epub 2023 Sep 16. PMID: 37717739.

Haumann F, Evangelakos I, Worthmann A, Liebold I, Kotschi S, Bischoff AT, Neuhofer CM, Schweizer M, Heine M, the mitoNET consortium, Büchner B, Klopstock T, Prehn C, Dyar KA, Prokisch H, Bosurgi L, Heeren J, Bartelt A, Kubisch C, Schlein C. Mitochondrial fatty acid synthesis is essential for coordinated energy transformation. medRxiv 2023.04.03.23288010; doi: https://doi.org/10.1101/2023.04.03.23288010

Liebscher G, Vujic N, Schreiber R, Heine M, Krebiehl C, Duta-Mare M, Lamberti G, de Smet CH, Hess MW, Eichmann TO, Hölzl S, Scheja L, Heeren J, Kratky D, Huber LA. The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue. Mol Metab. 2023 May;71:101705. doi: 10.1016/j.molmet.2023.101705. Epub 2023 Mar 11. PMID: 36907508; PMCID: PMC10074977.

Deline ML, Straub J, Patel M, Subba P, Grashei M, van Heijster FHA, Pirkwieser P, Somoza V, Livingstone JD, Beazely M, Kendall B, Gingras MJP, Leonenko Z, Höschen C, Harrington G, Kuellmer K, Bian W, Schilling F, Fisher MPA, Helgeson ME, Fromme T. Lithium isotopes differentially modify mitochondrial amorphous calcium phosphate cluster size distribution and calcium capacity. Front Physiol. 2023 Sep 15;14:1200119. doi: 10.3389/fphys.2023.1200119. PMID: 37781224; PMCID: PMC10540846.

U-Din M, de Mello VD, Tuomainen M, Raiko J, Niemi T, Fromme T, Klåvus A, Gautier N, Haimilahti K, Lehtonen M, Kristiansen K, Newman JW, Pietiläinen KH, Pihlajamäki J, Amri EZ, Klingenspor M, Nuutila P, Pirinen E, Hanhineva K, Virtanen KA. Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans. Cell Rep. 2023 Sep 26;42(9):113131. doi: 10.1016/j.celrep.2023.113131. Epub 2023 Sep 13. PMID: 37708023.

U-Din M, Rebelos E, Saari T, Niemi T, Kuellmer K, Eskola O, Fromme T, Rajander J, Taittonen M, Klingenspor M, Nuutila P, Nummenmaa L, Virtanen KA. Thermogenic Capacity of Human Supraclavicular Brown Fat and Cold-Stimulated Brain Glucose Metabolism. Metabolites. 2023 Mar 5;13(3):387. doi: 10.3390/metabo13030387. PMID: 36984827; PMCID: PMC10055954.

Hiefner J, Rische J, Bunders MJ, Worthmann A. A liquid chromatography-tandem mass spectrometry based method for the quantification of adenosine nucleotides and NAD precursors and products in various biological samples. Front Immunol. 2023 Sep 20;14:1250762. doi: 10.3389/fimmu.2023.1250762. PMID: 37799723; PMCID: PMC10548204.

Liebold I, Meyer S, Heine M, Kuhl A, Witt J, Eissing L, Fischer AW, Koop AC, Kluwe J, Wiesch JSZ, Wehmeyer M, Knippschild U, Scheja L, Heeren J, Bosurgi L, Worthmann A. TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD. Cells. 2023 Jan 17;12(3):341. doi: 10.3390/cells12030341. PMID: 36766683; PMCID: PMC9913311.

Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK. Taurine deficiency as a driver of aging. Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9. PMID: 37289866.

Benzi A, Spinelli S, Sturla L, Heine M, Fischer AW, Koch-Nolte F, Mittrücker HW, Guse AH, De Flora A, Heeren J, Bruzzone S. Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice. Cells. 2022 Nov 28;11(23):3812. doi: 10.3390/cells11233812. PMID: 36497069; PMCID: PMC9738612.

Fischer AW, Jaeckstein MY, Heeren J. Lysosomal acid lipase promotes endothelial proliferation in cold-activated adipose tissue. Adipocyte. 2022 Dec;11(1):28-33. doi: 10.1080/21623945.2021.2013416. PMID: 34957913; PMCID: PMC8726628.

Müller AL, Casar C, Preti M, Krzikalla D, Gottwick C, Averhoff P, Rosenstiel P, Gelderblom M, Altfeld M, Lohse AW, Steinmann S, Sebode M, Krause J, Schwinge D, Schramm C, Carambia A, Herkel J. Inflammatory type 2 conventional dendritic cells contribute to murine and human cholangitis. J Hepatol. 2022 Dec;77(6):1532-1544. doi: 10.1016/j.jhep.2022.06.025. Epub 2022 Jul 5. PMID: 35798133.

Evangelakos I, Kuhl A, Baguhl M, Schlein C, John C, Rohde JK, Heine M, Heeren J, Worthmann A. Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice. Front Cell Dev Biol. 2022 Apr 11;10:836741. doi: 10.3389/fcell.2022.836741. PMID: 35478959; PMCID: PMC9038073.

Bruder J, Fromme T. Global Adipose Tissue Remodeling During the First Month of Postnatal Life in Mice. Front Endocrinol (Lausanne). 2022 Feb 17;13:849877. doi: 10.3389/fendo.2022.849877. PMID: 35250892; PMCID: PMC8892685.

van Zwol, W; Rimbert, A; Wolters, J C.; Smit, M; Bloks, V W.; Kloosterhuis, N J.; Huijkman, N C. A.; Koster, M H.; Tharehalli, U; de Neck, S M.; Bournez, C; Fuh, M M.; Kuipers, J; Rajan, S; de Bruin, A; Ginsberg, H N.; van Westen, G J. P.; Hussain, M. M; Scheja, L; Heeren, J; Zimmerman, P; van de Sluis, B; Kuivenhoven, J A*. Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion. Hepatology ():p n/a, October 12, 2022. | DOI: 10.1002/hep.32709

Raimúndez E, Fedders M, Hasenauer J. Posterior marginalization accelerates Bayesian inference for dynamical systems. bioRxiv 2022.12.02.518841; doi: https://doi.org/10.1101/2022.12.02.518841

Till, A, Fries, C, Fenske, W.K. Brain-to-BAT - and Back?: Crosstalk between the Central Nervous System and Thermogenic Adipose  Tissue in Development and Therapy of Obesity. Brain Sci. 2022, 12, 1646. https://doi.org/10.3390/brainsci12121646

Sieckmann K, Winnerling N, Huebecker M, Leyendecker P, Ribeiro D, Gnad T, Pfeifer A, Wachten D, Hansen JN. AdipoQ - a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro. Mol Biol Cell. 2022 Aug 10;mbcE21110592. doi: 10.1091/mbc.E21-11-0592. Online ahead of print.

Niemann B, Haufs-Brusberg S, Puetz L, Feickert M, Jaeckstein MY, Hoffmann A, Zurkovic J, Heine M, Trautmann EM, Müller CE, Tönjes A, Schlein C, Jafari A, Eltzschig HK, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A. Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine. Nature. 2022 Sep;609(7926):361-368. doi: 10.1038/s41586-022-05041-0. Epub 2022 Jul 5. PMID: 35790189; PMCID: PMC9452294.

Münzker J, Haase N, Till A, Sucher R, Haange SB, Nemetschke L, Gnad T, Jäger E, Chen J, Riede SJ, Chakaroun R, Massier L, Kovacs P, Ost M, Rolle-Kampczyk U, Jehmlich N, Weiner J, Heiker JT, Klöting N, Seeger G, Morawski M, Keitel V, Pfeifer A, von Bergen M, Heeren J, Krügel U, Fenske WK. Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity. Microbiome. 2022 Jun 24;10(1):96. doi: 10.1186/s40168-022-01264-5. PMID: 35739571; PMCID: PMC9229785.

Oeckl J, Janovska P, Adamcova K, Bardova K, Brunner S, Dieckmann S, Ecker J, Fromme T, Funda J, Gantert T, Giansanti P, Hidrobo MS, Kuda O, Kuster B, Li Y, Pohl R, Schmitt S, Schweizer S, Zischka H, Zouhar P, Kopecky J, Klingenspor M. Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Mol Metab.
2022 Apr 22:101499. doi: 10.1016/j.molmet.2022.101499. Online ahead of print. PMID: 35470094

Thiemann E, Schwaerzer GK, Evangelakos I, Fuh MM, Jaeckstein MY, Behrens J, Nilsson SK, Kumari M, Scheja L, Pfeifer A, Heeren J, Heine M. Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling. Front Physiol.
2022 Mar 29;13:859671. doi: 10.3389/fphys.2022.859671. eCollection 2022. PMID: 35422714

Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. Commun Biol.
2022 Mar 29;5(1):280. doi: 10.1038/s42003-022-03201-6. PMID: 35351968

Rohde JK, Fuh MM, Evangelakos I, Pauly MJ, Schaltenberg N, Siracusa F, Gagliani N, Tödter K, Heeren J, Worthmann A. A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids. Metabolites.
2022 Feb 11;12(2):170. doi: 10.3390/metabo12020170. PMID: 35208244

Li Y, Fromme T. Uncoupling Protein 1 Does Not Produce Heat without Activation. Int J Mol Sci.
2022 Feb 22;23(5):2406. doi: 10.3390/ijms23052406. PMID: 35269549 

Heine M, Corban C, Heeren J. Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice. Methods Mol Biol.
2022;2448:107-118. doi:  10.1007/978-1-0716-2087-8_7. PMID: 35167093